ABSTRACT
Background: delayed onset muscle soreness [DOMS] is Common experience and prevalent after the unusual activity and exhaustive
Objective: The aim of this study was to evaluate the acute effect of supplementation Jdvar [Zedoary] and a single bout of exhaustive exercise on some indices of muscle damage men's handball
Methods: In this quasi-experimental study was conducted as double-blind, 12 handball players [mean age = 21.42 +/- 1.56 years, height = 186 +/- 5.85 cm, weight = 83.25 +/- 10 kg, BMI = 24.09 +/- 2.93 kg/m2] were divided randomly into two groups. Each group had a maximum Bruce protocol until exhaustion Previous [morning fasting] and immediately after the protocol were collected Blood samples from subjects. Then supplement group 3 capsules daily 500 milligram Jadvar and control group received 3 capsules daily 500 mg of maltodextrin for seven days. 24 hours after taking the last capsule subjects was performed maximum Bruce protocol to exhaustion and as the first protocol Blood samples were collected before and immediately after the protocol
Results: The results showed concentrations [CPK] serum after one week was increased in both group's supplementation and control; but concentration [LDH] after one week of supplementation reduced in both groups, but this increase and decrease were not significant in CPK and LDH
Conclusion: It seems that acute consumption Jadvar complete and exhaustive exercise not significant effect on levels of creatine kinase, lactate dehydrogenase in men handball
ABSTRACT
Physical activity energy expenditure may mediate the relationship between plasma leptin levels and worsening insulin resistance independent of adiposity. The purpose of this study was to investigate the effects of a single session of combined exercise on leptin levels and insulin resistance index in sedentary men. Ten male subjects [22.9 +/- 1.7 years] and BMI [23 +/- 1.7kg.m[-2]] performed a single session of combined exercise including aerobic exercise: 60-70% of their maximal oxygen consumption for 20 min, and resistance exercise: 2 sets of 10 repetitions at 70% of 1 repetition in maximum. Leptin, glucose, insulin and insulin resistance indexes were measured before and 24 h after an exercise. There were significant differences for leptin [ng.ml[-1]] [pre, 4.97[1.44]; post, 3.84[0.83]], and insulin resistance index [pre, 1.25[0.33]; post, 1.02[0.16]] [p<0.05]. But glucose [mmol.l[-1]] [pre, 4.4[0.42]; post, 4.25[0.4]], and insulin concentration [micro U.ml[-1] micro .ml[-1]] [pre, 5.8[0.74]; post, 5.39[0.48]] had significantly no changes after 24 h post-exercise. This study has suggested a single session of combined exercise along with a significant change of the leptin levels can affect positively on insulin resistance index
Subject(s)
Humans , Male , Exercise , Leptin , Insulin Resistance , Sedentary BehaviorABSTRACT
Esophageal squamous cell carcinoma [ESCC] is usually detected in advanced stages resulting in a very poor prognosis. Early diagnosis needs identification of clinically releveant precancerous lesions which could become the target of screening and early treatment. Our aim was to check whether esophagitis could serve as a relevant histological precursor of ESCC in Northern Iran. During 2001-2005, all adult patients who were referred to Atrak clinic for upper gastrointestinal endoscopy and biopsy were enrolled. Atrak clinic is a major center for upper gastrointestinal cancer research in eastern Golestan. All subjects had been complaining of upper GI symptoms and were under further investigation to rule out cancer. Biopsies from the endoscopically normal mid-esophagus and also just above the esophago-gastric junction were obtained in all subjects whose esophagus appeared normal during endoscopy and from endoscopically normal appearing mucosa at the proximal vicinity of any detected mass. Microscopic examinations for the verification of the presence or absence of esophagitis was performed by independent histological examination of the samples by two pathologists. All the discrepant diagnoses were resolved in joint diagnostic sessions. During the study period 836 patients were enrolled including 419 non cancer patients [endoscopy clinic controls], 387 cancer patients, and 30 subjects with clinical diagnosis of malignancy referred for histological reconfirmation of diagnosis by repeated biopsy. Mild or marked mid-esophagitis was diagnosed in 39 [9.3%], 47 [12.5%] and 12 [40%] of endoscopy clinic controls, cancer patients and those who were suspicious for upper gastrointestinal malignancies. Our observation does not show evidence for esophagitis to be a predisposing factor for ESCC in Gonbad region In North Eastern Iran
ABSTRACT
Base deficit is a well-characterized feature of occult tissue hypo-perfusion. However, its cut off point value for mortality in geriatric trauma has not been determined. In this study, the prediction value of base deficit and its cut off point were evaluated in old aged patients. In a prospective study, 300 old age [>=65 year] patients with trauma referred to All-Zahra hospital of Isfahan were studied. In each patient, arterial blood gas was taken and base deficit was checked. Risk factors of base deficit changes were determined. Patients were followed until death or discharge. The predictive probability of significant variables of mortality was tested by regression analysis. P value less than 0.05 was considered significant. Our results showed that in stable old aged traumatic patients base deficit was the only significant predictor of death [p<0.01]. A cut off value of 2.55 mmol/L had the best accuracy. Pelvis-AIS, GCS and cardiac disease were significant coefficient of base deficit changes [p<0.05]. Base deficit changes in range of 2.55-3 in old aged traumatic patients indicates occult tissue hypo-perfusion and increased mortality
Subject(s)
Humans , Geriatrics , Wounds and Injuries , Mortality , Prospective Studies , AgedABSTRACT
An increase in the number of intraepithelial lymphocytes [IEL] in the duodenal mucosa is an important criterion for the histological diagnosis of celiac disease [CD]. We determined the normal range for intraepithelial lymphocytes [IEL] in the second part of duodenum in healthy Iranian population. Four biopsy samples of the endoscopically normal appearing mucosa at the second part of duodenum were obtained from 50 individuals referred to Shariati hospitals [48 for epigastric pain, 2 for esophageal varices]. They had no sign, symptoms and evidence for malabsorption or small intestinal disorders in history, physical examination, Laboratory tests and IgA anti tissue transglutaminase [t.T.G]. Four-micrometer thick sections were stained with Hematoxillineosine [H and E] and immunohistochemistry [IHC] for leukocyte common antigen [LCA]. At least 500-600 cells from the tip and body of villi were counted separately and the number of IEL was given as mean/ 100 epithelial cells. The mean for IEL count in total villi in IHC method was 21/100 [23/100 in tip, 21/100 in body, p = 0.058] and 19/100 in H and E method [19/100 in tip, 18/100 in body, p =0.035] [p = 0.006]. Considering total villi, the normal upper limit [Mean+2SD] was calculated to be 35/100 in IHC and 34/100 in H and E stained sections and normal upper limit of confidence interval [the 95 percentile] was 39/100 in IHC and 37/100 in H and E stained sections. The villus height to crypt depth ratio was 3/94 in average. Respectively in IHC and H and E methods, the amounts equal or less than 35/100 and 34/100 are considered as normal., values between 35-39/100 and 34-37/100 as border line and counts more than 39/100 and 37/100 represent a pathology. Although the difference between two staining methods was statistically significant, considering cost effectiveness, we recommend H and E staining for routine clinical practice